Ever wondered how influential journals select content for publication and how peer review works? In this talk, I will discuss the editorial process at these journals, which typically rely on professional editors, focusing in particular on the Cell Press portoflio and introducing Newton, our new flagship physics journal. I will also share my views on current trends in scientific publishing, and provide tips on how to maximise the fit of your manuscript for high-impact journals and on how to deliver an appropriate reviewer report if you are invited to review a manuscript.